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Example Input Mode:
Partner Data
CBIS
Matrix
Example Data Type:
Secondary Screen (Kd)
Primary Screen(% control or competition)
If the input file contains Primary and Secondary Data, use:
Primary
Secondary
Assay Data File:
.txt or .csv format - download examples:
Bromodomain
Kd
Primary
To highlight spots, select a compound(s), click 'fill' and select entries.
Create Images for:
AC220
Highlight These Spots (
fill
):
AC220|CSF1R|10
AC220|DDR1|81
AC220|DDR2|1100
AC220|EPHA3|6500
AC220|EPHA6|9100
AC220|EPHA7|3700
AC220|EPHB6|1200
AC220|ERK8|270
AC220|FLT1|41
AC220|FLT3|1.3
AC220|FLT4|41
AC220|FRK|1800
AC220|HIPK4|320
AC220|KIT|4.8
AC220|LCK|2500
AC220|LOK|2100
AC220|LYN|5700
AC220|MAP4K4|2500
AC220|MAP4K5|440
AC220|MKNK2|2600
AC220|MLCK|410
AC220|MUSK|1000
AC220|PDGFRA|11
AC220|PDGFRB|7.7
AC220|RET|8
AC220|RIPK1|890
AC220|RIPK2|2700
AC220|SLK|4600
AC220|TAK1|8500
AC220|TIE1|3200
AC220|TNIK|2800
AC220|TRKA|2300
AC220|TRKB|620
AC220|TRKC|550
AC220|VEGFR2|87
AC220|YSK4|2000
AC220|CSF1R
AC220|DDR1
AC220|DDR2
AC220|EPHA3
AC220|EPHA6
AC220|EPHA7
AC220|EPHB6
AC220|ERK8
AC220|FLT1
AC220|FLT3
AC220|FLT4
AC220|FRK
AC220|HIPK4
AC220|KIT
AC220|LCK
AC220|LOK
AC220|LYN
AC220|MAP4K4
AC220|MAP4K5
AC220|MKNK2
AC220|MLCK
AC220|MUSK
AC220|PDGFRA
AC220|PDGFRB
AC220|RET
AC220|RIPK1
AC220|RIPK2
AC220|SLK
AC220|TAK1
AC220|TIE1
AC220|TNIK
AC220|TRKA
AC220|TRKB
AC220|TRKC
AC220|VEGFR2
AC220|YSK4
AC220|CSF1R|10
AC220|DDR1|81
AC220|DDR2|1100
AC220|EPHA3|6500
AC220|EPHA6|9100
AC220|EPHA7|3700
AC220|EPHB6|1200
AC220|ERK8|270
AC220|FLT1|41
AC220|FLT3|1.3
AC220|FLT4|41
AC220|FRK|1800
AC220|HIPK4|320
AC220|KIT|4.8
AC220|LCK|2500
AC220|LOK|2100
AC220|LYN|5700
AC220|MAP4K4|2500
AC220|MAP4K5|440
AC220|MKNK2|2600
AC220|MLCK|410
AC220|MUSK|1000
AC220|PDGFRA|11
AC220|PDGFRB|7.7
AC220|RET|8
AC220|RIPK1|890
AC220|RIPK2|2700
AC220|SLK|4600
AC220|TAK1|8500
AC220|TIE1|3200
AC220|TNIK|2800
AC220|TRKA|2300
AC220|TRKB|620
AC220|TRKC|550
AC220|VEGFR2|87
AC220|YSK4|2000
clear
Select Highlight spots color from Pallette:
(also used in table view)
Tree Image Options
Restore default options
Spot options:
IndianRed
PaleGreen
Gold
PowderBlue
Fill?
Outline?
Outline thickness:
1
2
3
4
5
Select Spots Color from Pallette:
(spot highlight color below)
micro
nano
Spot Size:
Scaling Factor:
.1
.2
.3
.4
.5
.6
.7
.8
.9
1
1.1
1.2
1.3
Area increase factor:
100%
90%
80%
70%
60%
50%
(per change of 10x Kd or 10% Competition)
Legend options:
Left align Text
Right align Text
Label options:
Compound Name?
Compound Name Font:
.5
1
1.5
2
Show Assay Panel information?
Show Panel Spots?
Append Concentration? (i.e., 'AB500@1000nm'; check before loading.)
Background Image:
Target labels?
Dark Tree Branch image?
Hide Lipid, Mutant, ATypical and Pathogen?
Spot options:
Spot Color transparency level:
none
low
medium-low
medium
high
no color
Spot Cutoff Value:
Kd (nM) (Blank for no cutoff)
Spot outline only?
Format:
JPEG(200KB per image)
Publication Quality(5MB image)
Create Publication Quality (5MB bitmap) Image for:
Select Compound
AC220
size/quality
100
90
80
70
60
50
40
30
% of original
White Space Border:
Yes
No
Preview and Highlighting
Highlight an assay by clicking on the spot or checking the box next to the Gene Symbol Name.
Click 'Update' to create the new images.
Compound To Highlight:
None
AC220
Highlight Panel?
* WildType kinase assays appear in both the main TREEspot and Mutant kinase dendrogams.
Human Kinome image created by KINOMEscan.
2 images created. To download (copy and paste) all images to your local machine click Open/Browse Image Folder.
Images Saved To:
D:\Eurofins\PROD\Applications\FrontOffice_Discovery\StudyManagement\TreeSpot\HTSTools\TreeImages\178_bdpdkljv4mkovuxht0cpjlol\
Open/Browse Image Folder
View Options:
(These options do not modify the images that have been created, only the view on this page)
AC220
Legend
Show Selected
Size:
Select Size
small
medium
full size
Images per Row:
1
Legend Resize?
Hover the cursor to identify spots and click to highlighted it. To save an image click the Zoom/Download link.
Zoom/Download
Highlight
Locate an Assay
CSF1R
DDR1
DDR2
EPHB6
ERK8
FLT1
FLT3
FLT3
FLT4
FRK
HIPK4
KIT
KIT
LCK
LOK
MAP4K4
MAP4K5
MKNK2
MLCK
MUSK
PDGFRA
PDGFRB
RET
RET
RIPK1
RIPK2
TNIK
TRKA
TRKB
TRKC
VEGFR2
YSK4
Legend
Data Table View:
Show All Data
Only Selected Compounds/Trees
TREE
spot
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